The friction f is the property of wall-bounded flows that sets the pumping cost of a pipeline, the draining capacity of a river, and other variables of practical relevance. For highly turbulent rough-walled pipe flows, f depends solely on the roughness length scale r, and the f - r relation may be expressed by the Strickler empirical scaling f ∝ r1/3 Here, we show experimentally that for soap film flows that are the two-dimensional (2D) equivalent of highly turbulent rough-walled pipe flows, f ∝ r and the f - r relation is not the same in 2D as in 3D. https://www.selleckchem.com/products/bms-345541.html Our findings are beyond the purview of the standard theory of friction but consistent with a competing theory in which f is linked to the turbulent spectrum via the spectral exponent α In 3D, α = 5/3 and the theory yields f ∝ r1/3; in 2D, α = 3 and the theory yields f ∝ r.Deficiency in the DNA end-processing enzyme, tyrosyl-DNA phosphodiesterase 1 (TDP1), causes progressive neurodegeneration in humans. Here, we generated a tdp1 knockout zebrafish and confirmed the lack of TDP1 activity. In adulthood, homozygotes exhibit hypersensitivity to topoisomerase 1 (Top1) poisons and a very mild locomotion defect. Unexpectedly, embryonic tdp1-/- zebrafish were not hypersensitive to Top1 poisons and did not exhibit increased Top1-DNA breaks. This is in contrast to the hypersensitivity of Tdp1-deficient vertebrate models reported to date. Tdp1 is dispensable in the zebrafish embryo with transcript levels down-regulated in response to Top1-DNA damage. In contrast, apex2 and ercc4 (xpf) transcripts were up-regulated. These findings identify the tdp1-/- zebrafish embryo as the first vertebrate model that does not require Tdp1 to protect from Top1-DNA damage and identify apex2 and ercc4 (xpf) as putative players fulfilling this role. It highlights the requirement of distinct DNA repair factors across the life span of vertebrates.Ultrafast and precise control of quantum systems at x-ray energies involves photons with oscillation periods below 1 as. Coherent dynamic control of quantum systems at these energies is one of the major challenges in hard x-ray quantum optics. Here, we demonstrate that the phase of a quantum system embedded in a solid can be coherently controlled via a quasi-particle with subattosecond accuracy. In particular, we tune the quantum phase of a collectively excited nuclear state via transient magnons with a precision of 1 zs and a timing stability below 50 ys. These small temporal shifts are monitored interferometrically via quantum beats between different hyperfine-split levels. The experiment demonstrates zeptosecond interferometry and shows that transient quasi-particles enable accurate control of quantum systems embedded in condensed matter environments.Natural genetic variation affects circadian rhythms across the evolutionary tree, but the underlying molecular mechanisms are poorly understood. We investigated population-level, molecular circadian clock variation by generating &gt;700 tissue-specific transcriptomes of Drosophila melanogaster (w1118 ) and 141 Drosophila Genetic Reference Panel (DGRP) lines. This comprehensive circadian gene expression atlas contains &gt;1700 cycling genes including previously unknown central circadian clock components and tissue-specific regulators. Furthermore, &gt;30% of DGRP lines exhibited aberrant circadian gene expression, revealing abundant genetic variation-mediated, intertissue circadian expression desynchrony. Genetic analysis of one line with the strongest deviating circadian expression uncovered a novel cry mutation that, as shown by protein structural modeling and brain immunohistochemistry, disrupts the light-driven flavin adenine dinucleotide cofactor photoreduction, providing in vivo support for the importance of this conserved photoentrainment mechanism. Together, our study revealed pervasive tissue-specific circadian expression variation with genetic variants acting upon tissue-specific regulatory networks to generate local gene expression oscillations.Comprehensive genomic analyses of small cell lung cancer (SCLC) have revealed frequent mutually exclusive genomic amplification of MYC family members. Hence, it has been long suggested that they are functionally equivalent; however, more recently, their expression has been associated with specific neuroendocrine markers and distinct histopathology. Here, we explored a previously undescribed role of L-Myc and c-Myc as lineage-determining factors contributing to SCLC molecular subtypes and histology. Integrated transcriptomic and epigenomic analyses showed that L-Myc and c-Myc impart neuronal and non-neuroendocrine-associated transcriptional programs, respectively, both associated with distinct SCLC lineage. Genetic replacement of c-Myc with L-Myc in c-Myc-SCLC induced a neuronal state but was insufficient to induce ASCL1-SCLC. In contrast, c-Myc induced transition from ASCL1-SCLC to NEUROD1-SCLC characterized by distinct large-cell neuroendocrine carcinoma-like histopathology. Collectively, we characterize a role of historically defined general oncogenes, c-Myc and L-Myc, for regulating lineage plasticity across molecular and histological subtypes.The Van Allen Probes mission provides unique measurements of the most energetic radiation belt electrons at ultrarelativistic energies. Simultaneous observations of plasma waves allow for the routine inference of total plasma number density, a parameter that is very difficult to measure directly. On the basis of long-term observations in 2015, we show that the underlying plasma density has a controlling effect over acceleration to ultrarelativistic energies, which occurs only when the plasma number density drops down to very low values (~10 cm-3). Such low density creates preferential conditions for local diffusive acceleration of electrons from hundreds of kilo-electron volts up to &gt;7 MeV. While previous models could not reproduce the local acceleration of electrons to such high energies, here we complement the observations with a numerical model to show that the conditions of extreme cold plasma depletion result in acceleration up to &gt;7 MeV.